The cees dekker Diaries
The cees dekker Diaries
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‘The 2nd is nanopores, which is our oldest line of research and which has now resulted in DNA sequencers determined by nanopores. We pull specific DNA strands by way of a nanopore and may then study off the nucleotide sequence. Very lately, we even managed to read out a single protein for The 1st time working with This method. But this line of analysis is not just about developing tools, but will also about authentic biological concerns.
1996, very first mesoscopic demand density waves devices; and 1st electrical measurements on a single steel nanocluster involving nanoelectrodes
Multicolor imaging of the bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
Non-equilibrium folding of personal DNA molecules recaptured around 1000 occasions inside a strong state nanopore
2010, created a fresh way (‘wedging transfer’) to govern nanostructures; to start with report of DNA translocation via graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into reliable-condition nanopores
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en satisfied 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks which assess the fundamental function of spatial confinement on the molecular and cellular level. Our projects include the following:
He also uncovered time to write down quite a few textbooks, send Just https://www.ceesdekker.net about forty thousand tweets and lead An effective investigate group at Delft College of Technologies. ‘It doesn’t sense like function’, he claims. ‘I’m just terribly curious.’
Comprehension elementary procedures regulating the spatial and dynamic organisation on the DNA in Stay cells.
Dekker started off his investigation on single carbon nanotubes in 1993 when he set up a completely new line of exploration to study electrical transportation as a result of one natural and organic molecules concerning nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was obtained in a very collaboration Together with the group of Nobel laureate Richard Smalley. STM and nanolithography methods were utilized to exhibit that these nanotubes are quantum wires at the single-molecule degree, with fantastic Actual physical Qualities.
An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
Later on we spoke once again briefly for the reason that Dekker felt that our discussion of his faith swiftly grew to become purely philosophical, While In addition it concretely assists him in his operate.
Developments in nanotechnology in the 1990s produced developing electronic gadgets from single molecules a chance. Cees Dekker recounts how his staff made a place-temperature transistor dependant on only one carbon nanotube.
2004, discovery of recent physics in translocation of DNA by nanopores; 1st experimental research of ions conduction in nanofluidic channels; to start with electrochemistry with particular person solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; initially electrical docking of microtubules on kinesin-coated nanostructures; very first biophysics characterization of the mechanical Houses of double-stranded RNA; and very first one-molecule examine of DNA translocation by a restriction-modification enzyme.